Spectra™ APCT & APTT Reagent A Comparison

Analytical Control Systems, Inc

Analytical Control Systems, Inc.

info@analyticalcontrols.com

Phone ACS

317-841-0458

Fax ACS

317-841-3186

Mail ACS

Analytical Control Systems, Inc.

9058 Technology Drive

Fishers, IN 46038

Many of Analytical Control Systems, Inc. products are covered by US and foreign patents or patents pending.

Individual Factor Deficiencies and Intrinsic System Reagents

Spectra™ APCT/APTT COMPARISON

The patented Spectra™ APCT test screens for PF3 but it does not give up its sensitivity to human plasma factor deficiencies in return for platelet testing.

The data below confirms that the patented Spectra™ APCT reagent both utilizes platelets to activate the intrinsic coagulation pathway and is sensitive to intrinsic coagulation factor deficiencies.

Sample	Spectra™ APCT	APTT (ACTIN™†)	APTT (Spectra™)
Normal Platelet Rich Plasma	30.8 sec	27.5 sec	25.4 sec
Factor II Deficient	90.8 sec	56.3 sec	58.6 sec
Factor V Deficient	89.6 sec	62.6 sec	70.5 sec
Factor VII Deficient	36.1 sec	37.8 sec	35.1 sec
Factor VIIIc Deficient	73.1 sec	53.3 sec	62.7 sec
Factor IX Deficient	84.7 sec	52.4 sec	67.3 sec
Factor X Deficient	74.8 sec	47.6 sec	64.9 sec
Factor XI Deficient	69.2 sec	86.1 sec	71.4 sec
Factor XII Deficient	98.7 sec	62.4 sec	72.6 sec
Fletcher Deficient	51.9 sec	35.2 sec	50.4 sec

† Actin is a trademark of Dade Behring

Table 1. In this comparison of the sensitivity of Spectra™ APCT, Dade Behring's APTT (Actin†) and ACS's APTT (Spectra™) to different factor deficiencies, Spectra™ APCT shows sensitivity to V, VIIIc, X, XI and Fletcher Factors and shows much greater sensitivity to II, IX and XII than either APTT reagents.

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